What Is Hydrocodone And How Does It Work?
Hydrocodone is one of the most prescribed pills in America. It is popular for its analgesic or pain fighting capabilities. The drug usually comes in some sort of mixture with acetaminophen also known as Tylenol or Norco. On the street, hydrocodone is usually referred to as hydro or hydros in the plural form.
Anyways, this article is going inform your on how does hydrocodone work and, furthermore, how do all or most opioids work. Opioids being all drugs like hydrocodone that have these effect on opioid receptors in your body and they all cause pretty similar effects just at varying intensities. So hydrocodone works on these series of opioid receptors located throughout the body. A lot of people think, well I was just in the brain or just in the spinal cord - no! They are located throughout the body.
There are, for example, kappa-receptors or delta receptors, but we are going to talk about Mu-receptor. There are mu 1 mu 2 and u mu 3 receptors. Hydrocodone other opioids bind at variant affinities, so what it's called. Basically, they all bind to these receptors at different strengths. Some bind really strongly some, bind not, but why we care about the Mu receptors more than of Kappa- or the Delta-receptors is because they bind to the Mu the strongest. And these are where a lot of the business effects happen that we care about the people abusing these drugs for that people use these drugs for medical yesterday is they bind these new receptors.
These mean receptors are located, like I said earlier, all throughout the body so the brain, the cortex of the brain, the thalamus the brain periaqueductal gray, all these different areas of the brain also in the spinal cord and in peripheral sensory neurons. So, when you feel the pain you feel these peripheral sensory neurons. Opioids like hydrocodone are going to work even in your periphery.
I'm going to draw a little brain here spinal, the cord is there in the peripheral neurons and then also it has receptors in the GI tract, which for those you who have taken opioids know that there is certain constipation associated with taking hydrocodone or other opioids. It happens because there are Mu-receptor centers located in all these different parts your body from that brain to the GI tract and real quick were to go through these Mu1 receptors. That's really going to deal with the analgesic for the pain killing part of the opioid.
The bad part about the Mu 1 receptors is also is where a lot of the dependency forms in front of people addicted to opioids, addicted to painkillers. That sort of thing is because of this Mu 1 receptor, which is where we do a lot of the pain killing, also has dependence.
But there is also Mu 2 opioid receptors in certain parts of the brain that control our respiratory systems, like the medulla right, controls our involuntary breathing. If we activate these receptors with an opioid were going to actually decrease our respirations. And this is where you hear about people being on long-term opioids or be on opioids. They have respiratory depression, not breathing as well the carbon dioxide increases that sort of thing there other effects associated with this Mu2- like meiosis, which is really getting the pinpoint pupils. It's tight little pupils that are where you know the cops pull you over and wonder, why your pupils are so pinpoint. That's because the Mu-2 receptors are activated and you get a little bit of euphoria and constipation when you take hydrocodone.
Mu-3 receptors. If you ask the pharmacist, I'm sure they tell you they know exactly what it is but am you through receptor there might be something to do with dilation, might be something to do with a little bit of analgesia. However, were not exactly sure what the Mu-3 does but in the ones to know our this new one is the opioid receptor. So, when you take hydrocodone or another opioid, it goes into your body, attaches to this guy very strongly and cuts out your pain as well as makes you feel good. It makes you have to form an addiction to it and it also hits Mu-2 receptors, which makes you breathe less and have the pinpoint pupils.
Now, how do you remember that hydrocodone and opioids cause pinpoint pupils while you think about heroin, which is commonly injected via syringe.
This is a short introduction of hydrocodone works through Mu receptors in the brain. The drug can be very addictive, that is why use it only according to your doctor's instructions.